Although no country have never before seceded from EU, somehow this remind me what happened in the US in the 1800's when 13 states seceded from the US for some same reasons why Britain voted leave EU. The centralization of power from the states to the federal government and lost of tax money to the very same all time growing central government and, of course, people's will to manage their own lives free from the dictatorial powers.
To be objective I must admit that what we see now in Europe is not exactly the same what happened in the US about one and a half century ago, but progression is similar; There is states managing them selves, then comes federal government in order to work for the benefit of the independent member states, the states are ruling the central government, then the federal government grow bigger, then it grow little bit more bigger and begins to rule the states, opposite what it was meant to be, democracy dies, some folks get angry, federal government gets angry trying to shut the mouths of whining people, people get more angry, and want to get rid of the monster they (or someone) made. Conflict. How many times the world have seen something like this over the history...?
When I was thinking about this a funny song came to my mind. It's a nice American folk song originally about a boy waiting for a wagon to bring hes loved one, but during the american civil war they made new lyrics for war propaganda purpose. And later Johnny Rebel made he's own lyrics. The song I'm performing in the youtube video below has lyrics mixed of those two song and I also made some modification to it to better suit in today's Europe... Ladies and gents, 'Dissolution Wagon' in style of Vallu The Author.
Just my two cents.